Erratum for: Titanium-Mediated Addition of Silyl Dienol Ethers to Electrophilic Glycine: 4-Ketopipecolic Acid Hydrochloride
نویسندگان
چکیده
منابع مشابه
Iodotrimethylsilane-mediated additions of dienol silyl ethers to .alpha.,.beta.-unsaturated ketones
Trimethylsily1)oxy-substituted dienes react with 1 at low temperatures to afford annulated products. Disciplines Chemistry | Environmental Chemistry | Inorganic Chemistry | Organic Chemistry | Other Chemistry | Polymer Chemistry Comments Reprinted (adapted) with permission from The Journal of Organic Chemistry, 49(6); 1153-1154. Doi: 10.1021/jo00180a048. Copyright 1984 American Chemical Society...
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Conjugate addition of organometallic reagents to enones to form silyl enol ether products is a versatile method to difunctionalize activated olefins, but the organometallic reagents required can be limiting. The reductive cross-electrophile coupling of unhindered primary alkyl bromides with enones and chlorosilanes to form silyl enol ether products is catalyzed by a nickel-complexed ortho-bromi...
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Mukaiyama Michael addition of silyl enol ethers 13 to the 1,2-quinone-4-carboxylate 6 (formed in situ by oxidation of the catechol ester 8) afforded the 2-subsituted 7-hydroxybenzofuran-4-carboxylates 14 in fair to good yields. Alkyl and aryl systems work well, but highly electron-rich silyl enol ethers could not be used because of competing oxidation.
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We describe here a Tf₂NH-catalyzed formal (3+3) cycloaddition of silyl enol ethers with acrylates as a new domino reaction. In the domino sequence, the catalyst activates Michael addition, deprotonation of the resulting silyloxonium cation and intramolecular Claisen condensation. It was found that reaction modes significantly depend on the reaction temperature. We also examined the mechanistic ...
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α-Chiral amines are of significant importance in medicinal chemistry, asymmetric synthesis and material science, but methods for their efficient synthesis are scarce. In particular, the synthesis of α-chiral amines with the challenging tetrasubstituted carbon stereocentre is a long-standing problem and catalytic asymmetric additions of organometallic reagents to ketimines that would give direct...
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ژورنال
عنوان ژورنال: Organic Syntheses
سال: 2016
ISSN: 2333-3553
DOI: 10.15227/orgsyn.093.0037